Laboratory Professionals

How the ThinPrep Imaging System Works

The ThinPrep Imaging System uses computer-assisted screening with an automated microscope to locate cells of interest. The ThinPrep Imaging System scans each patient slide, prioritizing areas of interest based on the DNA content of individual cells and cell clusters. Therefore, when an experienced cytotechnologist reviews an Imaged ThinPrep Pap Test slide, the areas of special interest are clearly marked for interpretation.

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ThinPrep Imaging System

How slides are evaluated

Specifically, a proprietary DNA stain is used to stain cervical cell nuclei. Abnormal cells have increased amounts of molecular DNA, and tend to be larger or irregularly shaped; also, the nuclei in abnormal cells take up more stain than the nuclei in normal cells. The presence of irregularly shaped, large, and darkly stained cells indicates that the sample may be abnormal.

The ThinPrep Imaging System scans each slide and identifies 22 fields that contain cells of interest. The cytotechnologist then reviews those 22 fields using an automated microscope and reports "no intraepithelial lesion" if all fields are judged to be normal. If the cytotechnologist judges cells in any field to be suspicious, the entire slide is reviewed by the cytotechnologist, who marks the abnormal cell groups for further review by a pathologist.

See why 70% of all ThinPrep Pap Tests are now imaged.

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