The ThinPrep Difference

International Studies:
Increased Disease Detection with
the ThinPrep Pap Test

As the ThinPrep Pap Test has become the most widely used liquid-based cytology in the United States, it has also gained wide acceptance around the world. Currently, more than 40 studies evaluating the benefits of ThinPrep Pap Test technology conducted outside of the United States have been published in peer-reviewed literature.

International Studies

Arbyn M, Bergeron C, Klinkhamer P, Martin-Hirsch P, Siebers AG, Bulten J. Liquid compared with conventional cytology. Obstet Gynecol. 2008;111:167-77.


Belinson J, Qiao YL, Pretorius R, Zhang WH, Elson P, Li L, Pan QJ, Fischer C, Lorincz A, Zahniser D. Shanxi province cervical cancer screening study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecol Oncol. 2001;83(2):439-44.


Bolger N, Heffron C, Regan I, Sweeney M, Kinsella S, McKeown M, Creighton G, Russell J, O’Leary J. Implementation and evaluation of a new automated interactive image analysis system. Acta Cytol. 2006;50(5):483-91.


Cheung AN, Szeto EF, Leung BS, Khoo US, Ng AW. Liquid-based cytology and conventional cervical smears: a comparison study in an Asian screening population. Cancer. 2003 Dec 25;99(6):331-5.


Clavel, Masure M, Bory JP, Putaud I, Mangeonjean C, Lorenzato M, Nazeyrollas P, Gabriel R, Quereux C, Birembault P. Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7,932 women. Br J Cancer. 2001;89(12):1616-23.


Cremer M, de LasCasas L, Kurtycz DFI, Schink J. Liquid-based cytology specimen studies to screen for cervical dysplasia in rural El Salvador. Int J Gynecol & Obstet. 2005 June 16; Epub ahead of print.


Cubie HA, Moore C, Waller M, Moss S; National Cervical Screening Committee LBC/HPV Pilot Steering Group. The development of a quality assurance programme for HPV testing within the UK NHS cervical screening LBC/HPV studies. J Clin Virol. 2005;33(4):287-92.


Davey E, d’Assuncao J, Irwig L, Macaskill P, Chan SF, Richards A, Farnsworth A. Accuracy of reading liquid based cytology slides using the ThinPrep Imager compared with conventional cytology: prospective study. British Medical Journal. 2007;335(7609):28.


Ferreccio C, Bratti MC, Sherman ME, et al. A comparison of single and combined visual, cytologic, and virologic tests as screening strategies in a region at high risk of cervical cancer. Cancer Epidemiol Biomarkers Prev. 2003;12:815-23.


Grace A, McBrearty P, Troost S, Thornhill M, Kay E, Leader M. Comparative study: conventional cervical and ThinPrep Pap tests in a routine clinical setting. Cytopathology. 2002;13(4):200-5.


Hoelund B. Implementation of liquid-based cytology in the screening programme against cervical cancer in the County of Funen, Denmark, and status for the first year. Cytopathology. 2003; 14(5):269-74.


Holund B, Grinsted P. [Screening for cervical cancer in the county of Funen. Status of 25 years of development and experiences]. Ugeskr Laeger. 2006;168(22):2163-6. Danish.


Hutchinson ML et al. Utility of liquid-based cytology for cervical carcinoma screening: results of a population-based study conducted in a region of Costa Rica with a high incidence of cervical carcinoma. Cancer (Cancer Cytopathol). 1999; 87(2):48-55.


Klinkhamer PJ, Meerding WJ, Rosier PF, Hanselaar AG. Liquid-based cervical cytology. Cancer. 2003;99(5):263-71.


Kothari A, Karim SZ, Gordon A, Raslan F, Abdalla M, George S. A comparative study of two devices used for cervical cell sampling raises some doubts about liquid-based cytology. Int J Gynecol Cancer. 2006;16:1579-86.


Kumar N, Massimo Bongiovanni M, Molliet MJ, Pelte MF, Egger JF, Pache JC. Reclassification and analysis of clinifal significance of atypical glandular cells on ThinPrep using The Bethesday 2001: Geneva experience. Swiss Med Wkly. 2007;137:635-41.


Liverani M, De Paola F, Danesi S, Fedriga R, Dalbuoni V, Agnoletti R, Amadori AR, Mirra F, Bonoli W, Saragoni L. [Applicative aspects of liquid-based cytology in cervical cancer screening]. Pathologica. 2006;98(6):629-34. [article in Italian]


Luthra, Chishti M, Dey P, Jolly SV, Abdulla M, Das DK, Sugathan TN, Ajrawi MT, George J, George SS, Aziz AA, Al-Juwaiser A, Karim FA, Mallik MK, Sheikh ZA, Khan S. Performance of monolayered cervical smears in a gynecology outpatient setting in Kuwait. Acta Cytol. 2002;46(2):303-10.


Malle D, Pateinakis P, Chakka E, Destouni C. Experience with a thin-layer, liquid-based cervical cytologic screening method. Acta Cytol. 2003;47(2):129-34.


Merea E, Le Gales C, Cochand-Priollet B, Cartier I, de Cremoux P, Vacher-Levenu MC, Vielh P, Coste J. Cost of screening for cancerous and precancerous lesions of the cervix. Diagn Cytopathol. 2002;27(4):251-7.


Monsonego J, et al. Liquid-based cytology for primary cervical cancer screening: a multi-centre study. Br J Cancer. 2001;84(3):360-6.


Murphy N, Ring M, Killalea AG, Uhlmann V, O'Donovan M, Mulcahy F, Turner M, McGuinness E, Griffin M, Martin C, Sheils O, O'Leary JJ. p16INK4A as a marker for cervical dyskaryosis: CIN and cGIN in cervical biopsies and ThinPrep smears. J Clin Pathol. 2003;56(1):56-63.


Nam JH, Kim HS, Lee JS, Choi HS, Min KW, Park CS. A comparison of modified MonoPrep2 of liquid-based cytology with ThinPrep Pap test. Gynecol Oncol. 2004 Sep;94(3):693-8.


Obwegeser JH, Brack S. Does liquid-based technology really improve detection of cervical neoplasia? A prospective, randomized trial comparing the ThinPrep Pap Test with the conventional Pap Test, including follow-up of HSIL cases. Acta Cytol. 200;45(5):709-14.


Pan Q, Belinson JL, Li L, Pretorius RG, Qiao YL, Zhang WH, Zhang X, Wu LY, Rong SD, Sun YT. A thin-layer, liquid-based Pap test for mass screening in an area of China with a high incidence of cervical carcinoma: a cross-sectional, comparative study. Acta Cytol. 2003;47(1):45-50.


Pan Q, Li L, Qiao Y. Comparative study on liquid-based cytology for cervical carcinoma screening in high-risk area of China. Zhonghua Zhong Liu Za Zhi. 2001 Jul;23(4):309-12.


Parham GP, Sahasrabuddhe VV, Mwanahamuntu MH, Shepherd BE, Hicks ML, Stringer EM, Vermund SH. Prevalence and predictors of squamous intraepithelial lesions of the cervix in HIV-infected women in Lusaka, Zambia. Gynecol Oncol. 2006 Jul 26; [Epub ahead of print]


Park IA, Lee SN, Chae SW, Park KH, Kim JW, Lee HP. Comparing the accuracy of ThinPrep Pap tests and conventional Papanicolaou smears on the basis of the histologic diagnosis: a clinical study of women with cervical abnormalities. Acta Cytol. 2001;45(4):525-31.


Qian DY, Cen JM, Wang D, Zeng RH, Lin AH, Shu YH, Hong DH, Huang ZH. Combining high-risk human papillomavirus DNA test and cytological test to detect early cervical dysplasia. Zhonghua Fu Chan Ke Za Zhi. 2006;41(1):34-7. [article in Chinese]


Rahimpanah F, Reid RI. Fallopian tube carcinoma detected by ThinPrep cytology smear. Med J Aust. 2000;17(1):38.


Ring M, Bolger N, O’Donnell M, Malkin A, Bermingham N, Akpan E, Mulcahy F, Turner NJ, Griffin M, O’Leary JJ. Evaluation of liquid-based cytology in cervical screening of high-risk populations: a split study of colposcopy and genito-urinary medicine populations. Cytopathology. 2002;13:152-9.


Roberts JM, et al. Evaluation of the ThinPrep Pap Test as an adjunct to the conventional Pap smear. Med J Aust. 1997;167:466-7.


Roberts JM, et al. Comparison of ThinPrep and Pap smear in relation to prediction of adenocarcinoma in situ. Acta Cytol. 1999;43(1):74-80.


Schledermann D, Ejersbo D, Hoelund B. Improvement of diagnostic accuracy and screening conditions with liquid-based cytology. Diagn Cytopathol. 2006;34(11):780-5.


Schledermann D, Ejersbo D, Hoelund B. Significance of atypia in conventional Papanicolaou smears and liquid-based cytology: a follow-up study. Cytopathology. 2004 Jun;15(3):148-53.


Schledermann D, Hyldebrandt T, Ejersbo D, Hoelund B. Automated screening versus manual screening: a comparison of the ThinPrep Imaging System and manual screening in a time study. Diagn Cytopathol. 2007;35(6):348-52.


Shield PW, et al. Improving cervical cytology screening in a remote, high risk population. Med J Aust. 1999;170(6):255-8.


Taylor S, Kuhn L, Dupree W, Denny L, De Souza M, Wright TC Jr. Direct comparison of liquid-based and conventional cytology in a South African screening trial. Int J Cancer. 2005;118(4):957-62.


Tuncer ZS, Basaran M, Sezgin Y, Firat P, Mocan Kuzey G. Clinical results of a split sample liquid-based cytology (ThinPrep) study of 4,322 patients in a Turkish institution. Eur J Gynaecol Oncol. 2005;26(6):646-8.


Wang TY, et al. Comparison of fluid-based, thin-layer processing and conventional Papanicolaou methods for uterine cervical cytology. J Formos Med Assoc. 1999;98(7):500-5.


Weintraub J, et al, Efficacy of a liquid-based thin layer method for cervical cancer screening in a population with a low incidence of cervical cancer. Diagn Cytopathol. 2000;22(1):52-9.


Yang Y, Wang YF, Lang JH, Cheng XM, Li CJ, Shan Y, Yu M. [Clinical evaluation of high-risk HPV detection by hybrid capture II in screening cervical intraepithelial neoplasma]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2006 Jun;28(3):395-8. [article in Chinese]


Yeoh GPS, et al. Evaluation of the ThinPrep Papanicolaou test in clinical practice: six-month study of 16, 541 cases with histological correlation in 220 cases. HKMJ 1999;5:233-9.

See clinical guidelines on pap testing, HPV testing, and imaging technology.

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