ThinPrep® Imaging System

The ThinPrep Imaging System is the first imaging directed screening or Dual Review™ system that combines the power of computerized imaging technology with human diagnostic experience. This Dual Review process provides improved diagnostic performance and screening productivity.¹

The ThinPrep Imaging System consists of:

Imaging Station
Image Processor Controller
Monitor and Keyboard
Automated Review Scopes each with a Navigator™ Pod and Keypad

Laboratory Workflow
The laboratory processes the ThinPrep Pap Tests on either the ThinPrep 2000 Processor or ThinPrep 3000 Processor. The slides are labeled, stained, coverslipped and then placed into a ThinPrep Imaging System cartridge. The cartridge is then placed in the Imaging Station, which rapidly scans and locates 22 areas of interest or fields of view (FOV) for every slide. The Image Processor then stores the coordinates of the FOVs along with the slide identification information. Once all of the slides in the cartridge have been imaged, the cytotechnologist removes the cartridge and takes it to the review scope where they will screen the slides. The Imaging Station can image up to 400 slides within a twenty-four hour period.

Cytotechnologist Workflow
Cytotechnologists review every slide with the ThinPrep Imaging System Review Scopes. The review scope automatically takes the cytotechnologist to each FOV in geographic order. The cytotechnologist evaluates each FOV, either selecting and electronically marking those areas that require further pathologist review or determining that the slide is negative and signing the case out. By directing the cytotechnologist to 22 FOVs on a slide, the amount of time required to screen a ThinPrep Pap Test slide is dramatically reduced.

Key areas of value that the ThinPrep Imaging System brings to the laboratory include:

Diagnostic confidence
Improved quality
Cytotechnologist satisfaction
Growth opportunities
Improved productivity

Addressing the issue of false negatives due to screening of slides
Approximately one third of false negative results are due to abnormal cells being missed or misclassified.² The innovative ThinPrep Imaging System makes imaging a Pap test a reality.

The first system to provide Dual Review™ whereby both the Imager and a cytotechnologist review every slide.

The first system that scans every cell and cell cluster and identifies areas of interest for further review.³

In the U.S. Clinical Trial, a 39% reduction in False Negative Fraction was reported for ASC-US+. In addition, the ThinPrep Imaging System provided a more accuarate diagnosis.*^3,4

The process that achieves a higher level of certainty in cervical screening.
The ThinPrep Imaging System is a new and innovative imaging technology for cervical cancer screening.

Requires consistent reproducible slide preparation.

Uses a quantitative stain to enable DNA nuclear measurements by computer.

Integrates a computer and human for review of every slide to ensure a more accurate result.

ThinPrep Technology

New Quantitative ThinPrep Stain

Provides consistent, reproducible results⁵

Ensures a representative transfer of cells from vial to slide

Produces a well visualized thin-layer slide

FDA-approved for adjunctive HPV, chlamydia, and gonorrhea testing

Results in reduced variability

Features a proprietary, pre-formulated staining process

Allows measurement of cellular DNA content

Cells can be more accurately assessed for abnormalities

The New ThinPrep Imaging System

Dual Review

Improves diagnostic capability for greater accuracy³

ThinPrep Imaging System scans every cell and cell cluster

Measures of nuclear morphology are used to identify "areas of interest"

The cytotechnologist can better focus his or her interpretive skills on these defined areas

Integrates computer and human review for more accurate diagnosis

Provides Dual Review - ThinPrep Imaging System prescreens over the slide and selects "areas of interest" for the cytotechnologist

Increases sensitivity (based on a cut-off point of ASC-US+) vs. manual screening

Improves specificity (based on a cut-off point of HSIL+) vs. manual screening³

ThinPrep Pap Test slide

Cytotechnologist reviews "areas of interest"

For additional information, please refer to our ThinPrep Imaging System brochure in PDF format.

In order to access this PDF file, you will need the Adobe® Acrobat® Reader™ plug-in. If necessary, read the instructions below to obtain a copy of the plug-in.

Click here to go to the Adobe Acrobat Reader download site.
Read through the steps provided on Adobe's site and select the correct version of the plug-in for your computer.
When the download is complete, click on the downloaded file to install the plug-in and follow the directions on your screen.
When the setup is finished, the plug-in will be installed.

* Based on a cut-off point of ASC-US+
¹ ThinPrep Imaging System Package Insert P/N 86093-001
² Gay JD, Donaldson LD, Goellner JR. False-negative results in cervical cytologic studies. Acta Cytol. 1985;29:1043-1046.
³ Based on a statistically significant improvement in sensitivity for ASC-US+ and a statistically significant improvement in specificity for HSIL+ from the ThinPrep Imaging System Clinical Trial. Reference: ThinPrep Imaging System Operation Summary and Clinical Information.
⁴ A more accurate diagnosis is based on sensitivity of ASC-US+, and specificity is based on HSIL+. Reference: ThinPrep Imaging System Operation.
⁵ Hutchinson ML, Isenstein LM, Goodman A, et al. Homogeneous sampling accounts for the increased diagnostic accuracy using the ThinPrep Processor. Am J Clin Pathol. 1994;101:215-219.

The ThinPrep Imaging System is the first Dual Review system.